[논문발표 PPT] RhoA Prenylation Inhibitor Produces Relaxation of Tonic Smooth Muscle of Internal Anal Sphincter

of intestinal motilityInhibition of painStimulation of acid secretionRegulation of pyloric sphincter, colonic contractionModulation of salt, water absorption(Presynaptic inhibition of Ach secretion in myenteric plexus)2.Substance P & Other TachykininsSubstance P - stimulatory neuropeptidePromote conduction of peristaltic contractionIncrease LES pressureConduction of pain impulseSubstance K - motility modulator3.Vasoactive Intestinal Polypeptide (VIP)3 Major Types of Effect① Relaxation of Smooth MuscleInternal anal sphincterLESEsophageal distension -> upper stomach distensio

of intestinal motilityInhibition of painStimulation of acid secretionRegulation of pyloric sphincter, colonic contractionModulation of salt, water absorption(Presynaptic inhibition of Ach secretion in myenteric plexus)2.Substance P & Other TachykininsSubstance P - stimulatory neuropeptidePromote conduction of peristaltic contractionIncrease LES pressureConduction of pain impulseSubstance K - motility modulator3.Vasoactive Intestinal Polypeptide (VIP)3 Major Types of Effect① Relaxation of Smooth MuscleInternal anal sphincterLESEsophageal distension -> upper stomach distensio

of intestinal motilityInhibition of painStimulation of acid secretionRegulation of pyloric sphincter, colonic contractionModulation of salt, water absorption(Presynaptic inhibition of Ach secretion in myenteric plexus)2.Substance P & Other TachykininsSubstance P - stimulatory neuropeptidePromote conduction of peristaltic contractionIncrease LES pressureConduction of pain impulseSubstance K - motility modulator3.Vasoactive Intestinal Polypeptide (VIP)3 Major Types of Effect① Relaxation of Smooth MuscleInternal anal sphincterLESEsophageal distension -> upper stomach distensio

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